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(S,R,S)-AHPC TFA

CAS No. 1631137-51-3

(S,R,S)-AHPC TFA ( VH032-NH2 TFA; VHL ligand 1 TFA )

产品货号. M26954 CAS No. 1631137-51-3

(S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
5MG ¥3321 有现货
10MG ¥4836 有现货
25MG ¥7881 有现货
50MG ¥10449 有现货
100MG ¥14337 有现货
500MG ¥28755 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    (S,R,S)-AHPC TFA
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    (S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein.
  • 产品描述
    (S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
  • 同义词
    VH032-NH2 TFA; VHL ligand 1 TFA
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    hERG; σ1
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    1631137-51-3
  • 分子量
    544.6
  • 分子式
    C24H31F3N4O5S
  • 纯度
    >98% (HPLC)
  • 溶解度
    ——
  • SMILES
    OC(=O)C(F)(F)F.Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.
产品手册
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