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(S,R,S)-AHPC TFA
CAS No. 1631137-51-3
(S,R,S)-AHPC TFA ( VH032-NH2 TFA | VHL ligand 1 TFA )
产品货号. M26954 CAS No. 1631137-51-3
(S,R,S)-AHPC TFA (VH032-NH2 TFA) 是基于 VH032 的 VHL 配体，用于招募 von Hippel-Lindau (VHL) 蛋白。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥3321 | 有现货 |
|
| 10MG | ￥4836 | 有现货 |
|
| 25MG | ￥7881 | 有现货 |
|
| 50MG | ￥10449 | 有现货 |
|
| 100MG | ￥14337 | 有现货 |
|
| 500MG | ￥28755 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称(S,R,S)-AHPC TFA
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述(S,R,S)-AHPC TFA (VH032-NH2 TFA) 是基于 VH032 的 VHL 配体，用于招募 von Hippel-Lindau (VHL) 蛋白。
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产品描述(S,R,S)-AHPC TFA (VH032-NH2 TFA) is the VH032-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. (S,R,S)-AHPC TFA can be connected to the ligand for protein (e.g., BCR-ABL1) by a linker to form PROTACs (e.g., GMB-475). GMB-475 induces the degradation of BCR-ABL1 with an IC50 of 1.11 μM in Ba/F3 cells.
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体外实验——
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体内实验——
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同义词VH032-NH2 TFA | VHL ligand 1 TFA
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通路Others
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靶点Other Targets
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受体hERG| σ1
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研究领域——
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适应症——
化学信息
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CAS Number1631137-51-3
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分子量544.59
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分子式C24H31F3N4O5S
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纯度>98% (HPLC)
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溶解度——
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SMILESOC(=O)C(F)(F)F.Cc1ncsc1-c1ccc(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](N)C(C)(C)C)cc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.
产品手册
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